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1581

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2

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35

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39

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191

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12

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6792
    T-2 Toxin
    1 Publications Verification

    T-2 Mycotoxin

    		 Apoptosis DNA/RNA Synthesis Metabolic Disease
    T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates . T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides . T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .
    <em>T</em>-2 Toxin
  • HY-W015764
    T-1105
    1 Publications Verification

    		 Flavivirus Infection
    T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase .
    <em>T</em>-1105
  • HY-N8039
    Ganoderic acid T-Q

    Ganodermic acid T-Q

    		 Microtubule/Tubulin Cancer
    Ganoderic acid T-Q (Ganodermic acid T-Q) (compound 1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid T-Q stimulates tubulin polymerization .
    Ganoderic acid <em>T</em>-Q
  • HY-N6720
    T-2 Triol

    		Endogenous Metabolite Metabolic Disease
    T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .
    <em>T</em>-2 Triol
  • HY-100682
    T-3256336

    T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity .
    <em>T</em>-3256336
  • HY-105349
    T-0156

    		Phosphodiesterase (PDE) Neurological Disease
    T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway .
    <em>T</em>-0156
  • HY-125930
    T-2513

    		Topoisomerase DNA/RNA Synthesis Cancer
    T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
    <em>T</em>-2513
  • HY-125930A
    T-2513 hydrochloride

    		Topoisomerase DNA/RNA Synthesis Cancer
    T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
    <em>T</em>-2513 hydrochloride
  • HY-161307
    T-518

    		HDAC Neurological Disease
    T-518 is an orally active, selective, and blood-brain barrier permeable HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6. T-581 can be used in research on tauopathy .
    <em>T</em>-518
  • HY-N6721
    T-​2 Tetraol

    		Others Infection
    T-​2 Tetraol is a metabolite of T-2 toxin, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis .
    <em>T</em>-​2 Tetraol
  • HY-19352
    T56-LIMKi
    1 Publications Verification

    T5601640

    		 LIM Kinase (LIMK) Cancer
    T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
    <em>T</em>56-LIMKi
  • HY-106158
    T-1095

    		SGLT Metabolic Disease
    T-1095 is a selective and orally active Na +-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research .
    <em>T</em>-1095
  • HY-122635A
    T-448

    		Histone Demethylase Neurological Disease
    T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons .
    <em>T</em>-448
  • HY-B0959
    Chloramine-T

    		Bacterial Infection
    Chloramine-T is a titrimetric reagent, and an oxidizing agent. Chloramine-T is an oxidizing biocide .
    Chloramine-<em>T</em>
  • HY-136498
    T-705RMP

    		Drug Metabolite Infection
    T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
    <em>T</em>-705RMP
  • HY-B0724B
    Pazufloxacin

    T3761

    		 Bacterial Antibiotic Infection
    Pazufloxacin (T-3761) is a fluoroquinolone antibiotic.
    Pazufloxacin
  • HY-161045
    T-1-DOCA

    		EGFR Apoptosis Cancer
    T-1-DOCA ia a EGFR inhibitor, with the IC50 of 56.94 and 269.01?nM for EGFR WT and EGFR T790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells .
    <em>T</em>-1-DOCA
  • HY-N10375
    Kuwanon T

    		Others Others
    Kuwanon T is an isoprenylated flavonoid compound isolated from the root bark of Morus alba. Kuwanon T shows protective effects on t-BHP-induced oxidative stress with a EC50 of 30.32 μM .
    Kuwanon <em>T</em>
  • HY-102045
    T-3764518

    		Stearoyl-CoA Desaturase (SCD) Metabolic Disease
    T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.
    <em>T</em>-3764518
  • HY-142102
    T988C

    (+)-T988C

    		 Others Cancer
    T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .
    <em>T</em>988C
  • HY-110251
    DFHBI-1T
    5+ Cited Publications

    		 DNA Stain Others
    DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells .
    DFHBI-1<em>T</em>
  • HY-162064
    T-1-MBHEPA

    		VEGFR Cancer
    T-1-MBHEPA is a potent inhibitor of VEGFR-2, with the IC50 value of 0.121±0.051 μM. T-1-MBHEPA has anti-tumor and anti-angiogenic effect .
    <em>T</em>-1-MBHEPA
  • HY-158149
    T-1-PMPA

    		EGFR Apoptosis Cancer
    T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively .
    <em>T</em>-1-PMPA
  • HY-W190966
    t-Boc-Aminooxy-PEG4-t-butyl ester

    		PROTAC Linkers Others
    t-Boc-Aminooxy-PEG4-t-butyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    <em>t</em>-Boc-Aminooxy-PEG4-<em>t</em>-butyl ester
  • HY-156452
    T-1-MCPAB

    		VEGFR Cancer
    T-1-MCPAB is a VEGFR-2 inhibitor (IC50=0.135 µM) that effectively inhibits MCF7 migration. T-1-MCPAB can be used in cancer research .
    <em>T</em>-1-MCPAB
  • HY-13202S
    T0070907-d4

    		Isotope-Labeled Compounds Cancer
    T0070907-d4 is the deuterium labeled T0070907 (HY-13202). T0070907 is a potent PPARγ antagonist .
    <em>T</em>0070907-d4
  • HY-110251A
    DFHBI-2T

    		DNA Stain Others
    DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells .
    DFHBI-2<em>T</em>
  • HY-163028
    ML-T7

    		Tim3 Cancer
    ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .
    ML-<em>T</em>7
  • HY-103085
    T-3775440 hydrochloride
    2 Publications Verification

    		 Histone Demethylase Cancer
    T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.
    <em>T</em>-3775440 hydrochloride
  • HY-N6792S
    T-2 Toxin-13C24

    T-2 Mycotoxin-13C24

    		 Isotope-Labeled Compounds Metabolic Disease
    T-2 Toxin- 13C24 (T-2 Mycotoxin- 13C24) is 13C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .
    <em>T</em>-2 Toxin-13C24
  • HY-N11648
    Ganoderic acid T1

    		Apoptosis Caspase Inflammation/Immunology Cancer
    Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .
    Ganoderic acid <em>T</em>1
  • HY-114220
    T-2307

    		Fungal Infection
    T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
    <em>T</em>-2307
  • HY-162045
    Ru-4T

    		Others Cancer
    Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC50 values of 740 pM .
    Ru-4<em>T</em>
  • HY-114271A
    T3-ATA (S-isomer)

    		Thyroid Hormone Receptor Endocrinology
    T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.
    <em>T</em>3-ATA (S-isomer)
  • HY-114272A
    T4-ATA (S-isomer)

    		Thyroid Hormone Receptor Endocrinology
    T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
    <em>T</em>4-ATA (S-isomer)
  • HY-160067
    T18.3 aptamer sodium

    		Others Infection
    T18.3 aptamer sodium is an anticoagulant RNA aptamer targeting FV/Va and eliminates the interaction of FV/FVa with phospholipid membranes. T18.3 aptamer sodium exhibits clinically relevant anticoagulant activity in plasma and whole blood and acts synergistically with low molecular weight heparin. The anticoagulant activity of T18.3 aptamer sodium is effectively and rapidly reversed by protamine sulfate .
    <em>T</em>18.3 aptamer sodium
  • HY-P0229
    Ribonulease T1, Aspergillus oryzae

    Rnase T1

    		 DNA/RNA Synthesis Others
    Ribonulease T1, Aspergillus oryzae (Rnase T1), is commonly used in biochemical research. Ribonuclease T1 is an endonuclease that can specifically degrade single stranded RNA. Ribonuclease T1 can form nucleoside 2 ', 3 '-cyclic phosphoric acid intermediates to cut the phosphodiester bond between 3' -guanosine residues and adjacent nucleoside 5 '-OH groups to produce 3' -GMP terminal oligonucleotides .
    Ribonulease <em>T</em>1, Aspergillus oryzae
  • HY-10626
    T0901317
    20+ Cited Publications

    		 LXR FXR ROR Apoptosis Cardiovascular Disease Metabolic Disease Cancer
    T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα . T0901317 activates FXR with an EC50 of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .
    <em>T</em>0901317
  • HY-P1115
    AKTide-2T

    		Akt Others
    AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
    AKTide-2<em>T</em>
  • HY-146404
    T761-0184

    		nAChR Neurological Disease
    T761-0184 is a potent α7 nicotinic receptor (nAChR) antagonist .
    <em>T</em>761-0184
  • HY-148185
    T01-1

    		ADC Cytotoxin Cancer
    T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .
    <em>T</em>01-1
  • HY-P5981
    Chromozym t-PA

    		Biochemical Assay Reagents Others
    Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration
    Chromozym <em>t</em>-PA
  • HY-125961
    T3Inh-1

    		Others Cancer
    T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 µM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) .
    <em>T</em>3Inh-1
  • HY-P2251
    T-peptide

    		HIV Microtubule/Tubulin Infection Inflammation/Immunology Cancer
    T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection .
    <em>T</em>-peptide
  • HY-160068
    2-2(t) aptamer sodium

    		EGFR Cancer
    2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo .
    2-2(<em>t</em>) aptamer sodium
  • HY-119690
    T326

    		HDAC HIV Infection Cancer
    T326 is a potent and selective HDAC3 inhibitor, with an IC50 of 0.26 μM. T326 can be used for the research of cancer and HIV infection .
    <em>T</em>326
  • HY-155230
    T3SS-IN-2

    		Bacterial Infection
    T3SS-IN-2 (Compound 2h) is a type three secretion system (T3SS) inhibitor. T3SS-IN-2 can be used for bacterial infection research .
    <em>T</em>3SS-IN-2
  • HY-12270
    T-5224
    45+ Cited Publications

    		 AP-1 MMP Others
    T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
    <em>T</em>-5224
  • HY-107533
    T-98475

    		GnRH Receptor Endocrinology
    T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM .
    <em>T</em>-98475
  • HY-120356A
    T-1101 tosylate

    TAI-95 tosylate

    		 Apoptosis Cancer
    T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG
    <em>T</em>-1101 tosylate

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